Analysis of Protein Array containing more than 19,000 full-length human proteins using CD68 Mouse Monoclonal Antibody (LAMP4/1830) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using CD68 Mouse Monoclonal Antibody (LAMP4/1830) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.SDS-PAGE Analysis Purified CD68 Mouse Monoclonal Antibody (LAMP4/1830).Confirmation of Integrity and Purity of Antibody.

CD68 (Macrophage Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 159.00$ 349.00
Please Select A Product To View The SKU.

SKU: 968-MSM6
Species: Human
Tested Applications: Flow, IF, WB, IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b, kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 968-MSM6-P0
CD68 (Macrophage Marker) General Information
Alternate Names
GP110, LAMP4, Microsialin, Macrosialin, SCARD1, Scavenger Receptor Class D Member-1
Molecular Weight
110kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol968
Entrez Gene IDCD68
UniProt ID(s)P34810
UniGene ID(s)Hs647419
COSMIC ID Link(s)CD68
KEGG Gene ID(s)hsa:968
General Description of CD68 (Macrophage Marker).
This antibody recognizes a glycoprotein of 110kDa, which is identified as CD68. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. It reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Lymphomas are negative or show few granules.

Human Anti-CD68 (Macrophage Marker) Antibody Product Attributes

Species: Human
Tested Applications: Flow, IF, WB, IHC.
Clonality: Monoclonal
Anti-CD68 (Macrophage Marker) Antibody Clone: LAMP4/1830
Clone LAMP4/1830 Host and Isotype: Mouse IgG2b, kappa
Anti-Human CD68 (Macrophage Marker) Positive Control Sample: Tonsil, Lymph Node or Spleen
Cellular Localization of Antibody LAMP4/1830 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human CD68 protein (apprx. aa 150-301) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

CD68 (Macrophage Marker) Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CD68 antibody staining is expected to be primarily localized to the vesicles and golgi apparatus.

Observed Antibody Staining Data By Tissue Type:

Variations in CD68 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the red pulp in spleen and macrophages in lung. More moderate antibody staining intensity was present in cells in the red pulp in spleen and macrophages in lung. Low, but measureable presence of CD68 could be seen inglial cells in the cerebral cortex. We were unable to detect CD68 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's product, CD68 (Macrophage Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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CD68 (Macrophage Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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