SDS-PAGE Analysis Purified CD8 Mouse Recombinant Monoclonal Antibody (rC8/468).Confirmation of Purity and Integrity of Antibody.
SDS-PAGE Analysis Purified CD8 Mouse Recombinant Monoclonal Antibody (rC8/468).Confirmation of Purity and Integrity of Antibody.

CD8A (Cytotoxic-&Suppressor T-Cell Marker) MonoSpecific Antibody

$ 199.00$ 429.00
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SKU: 925-MSM11
Species: Human
Tested Applications: Flow, IF, IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

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In Stock: 1-2 Day Lead Time.
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Datasheets and Documentation
Product Datasheet
SKU: 925-MSM11-P0
CD8A (Cytotoxic-&Suppressor T-Cell Marker) General Information
Alternate Names
CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain
Molecular Weight
32kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol925
Entrez Gene IDCD8A
UniProt ID(s)P01732
UniGene ID(s)Hs85258
COSMIC ID Link(s)CD8A
KEGG Gene ID(s)hsa:925
General Description of CD8A (Cytotoxic-&Suppressor T-Cell Marker).
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4.It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Human Anti-CD8A (Cytotoxic-&Suppressor T-Cell Marker) Antibody Product Attributes

Species: Human
Tested Applications: Flow, IF, IHC.
Clonality: Monoclonal
Anti-CD8A (Cytotoxic-&Suppressor T-Cell Marker) Antibody Clone: rC8/468
Clone rC8/468 Host and Isotype: Mouse IgG1
Anti-Human CD8A (Cytotoxic-&Suppressor T-Cell Marker) Positive Control Sample: HuT78 or hPBL. Tonsil
Cellular Localization of Antibody rC8/468 Staining: Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human CD8 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

CD8A (Cytotoxic-&Suppressor T-Cell Marker) Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD8A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the red pulp in spleen, cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the red pulp in spleen, cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD8A could be seen inmacrophages in lung. We were unable to detect CD8A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's product, CD8A (Cytotoxic-&Suppressor T-Cell Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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