Anti-gp100 Specificity Assay (Array)
FFPE human melanoma sections stained with 100 ul anti-gp100 (clone PMEL/2038) at 1:50. HIER epitope retrieval prior to staining was performed in 10mM Citrate, pH 6.0.FFPE human skin sections stained with 100 ul anti-gp100 (clone PMEL/2038) at 1:300. HIER epitope retrieval prior to staining was performed in 10mM Citrate, pH 6.0.Data from SDS-PAGE analysis of Anti-gp100 antibody (Clone PMEL/2038). Reducing lane (R) shows heavy and light chain fragments. NR lane shows intact antibody with expected MW of approximately 150 kDa. The data are consistent with a high purity, intact mAb.SDS-PAGE Analysis Purified gp100 Mouse Monoclonal Antibody (PMEL/2038).Confirmation of Integrity and Purity of Antibody.

gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 158.00$ 348.00
Please Select Product Options Below To View The Catalog Number.

SKU: 6490-MSM8
Species: Human
Tested Applications: IHC, ELISA
Available Conjugates: Unconjugated
Isotype: Mouse IgG1, kappa
Mass Spec Validated?: Not MS Validated

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Shipping Information
In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: 6490-MSM8-P0
gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) General Information
Alternate Names
95kDa melanocyte-specific secreted glycoprotein, M-beta; Melanocyte lineage specific antigen GP100; Melanocyte protein Pmel 17; Melanoma associated ME20 antigen; Melanosomal matrix protein17; Premelanosome protein (PMEL17); Secreted melanoma-associated ME20 antigen; SILV; Silver homolog
Molecular Weight
90-100kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol6490
Entrez Gene IDSILV
UniProt ID(s)P40967
UniGene ID(s)Hs95972
COSMIC ID Link(s)SILV
KEGG Gene ID(s)hsa:6490
General Description of gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker).
Cytotoxic T lymphocytes (CTL s) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.

Human Anti-gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody Product Attributes

Species: Human
Tested Applications: IHC, ELISA.
Clonality: Monoclonal
Anti-gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody Clone: PMEL/2038
Clone PMEL/2038 Host and Isotype: Mouse IgG1, kappa
Anti-Human gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Positive Control Sample: SK-MEL-28 cells or Melanoma
Cellular Localization of Antibody PMEL/2038 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant human SILV protein fragment (apprx. aa 376-502) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Ultraspecific Antibody

Tested against >20,000 Human Proteins

https://enquirebio.com/wp-content/uploads/2019/01/Anti-gp100 Specificity Assay (Array)-300x120.jpghttps://enquirebio.com/wp-content/uploads/2019/01/gp100 IHC human Melanoma (PMEL 2038)-300x225.jpghttps://enquirebio.com/wp-content/uploads/2019/01/gp100 IHC human Skin (PMEL 2038)-300x225.jpghttps://enquirebio.com/wp-content/uploads/2019/01/Anti-gp100(PMEL 2038) Gel-218x300.jpghttps://enquirebio.com/wp-content/uploads/2018/06/enQuire-Bio-6490-MSM8-P0-anti-gp100-Melanosome-PMEL17-SILV-Melanoma-Marker-antibody-1-218x300.jpeg