SDS-PAGE Analysis Purified Granzyme B Mouse Monoclonal Antibody (GZMB/2403).Confirmation of Integrity and Purity of Antibody.

Analysis of Protein Array containing >19,000 full-length human proteins using Granzyme B Mouse Monoclonal Antibody (GZMB/2403) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SDs) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SDs) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Formalin-fixed, paraffin-embedded human Spleen stained with Granzyme B Mouse Monoclonal Antibody (GZMB/2403).

Granzyme B (NK/T-Cell Lymphoma Marker) Ultraspecific Antibody
Tested against >20,000 Human Proteins

Name: Granzyme B (NK/T-Cell Lymphoma Marker) Ultraspecific Antibody <p style="font-size:small">Tested against &gt;20,000 Human Proteins</p>
SKU: 3002-MSM3-P0
Availability: InStock

$ 199.00 – $ 429.00

Please Select Product Options Below To View The Catalog Number.

SKU: 3002-MSM3
Species: Human
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b
Mass Spec Validated?: Not MS Validated

Product Number	Description	Price
3002-MSM3-P0	Size: 20 ug, Tag: Unconjugated	$ 199.00
3002-MSM3-P1	Size: 100 ug, Tag: Unconjugated	$ 429.00
3002-MSM3-P1ABX	Size: 100 ug, Tag: Unconjugated	$ 429.00

Shipping Information

In Stock.

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: 3002-MSM3-P0

Granzyme B (NK/T-Cell Lymphoma Marker) General Information
Alternate Names
Cathepsin G-like 1; CCPI; CGL1; CSPB; CTLA-1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; Granzyme B; Granzyme-2; GRB; Gzmb; Human lymphocyte protein (Hlp); Lymphocyte protease; SECT; T-cell serine protease 1-3E
Molecular Weight
29-32kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol	3002
Entrez Gene ID	GZMB
UniProt ID(s)	P10144
UniGene ID(s)	Hs1051
COSMIC ID Link(s)	GZMB
KEGG Gene ID(s)	hsa:3002
General Description of Granzyme B (NK/T-Cell Lymphoma Marker).
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

Human Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Antibody Product Attributes

Species: Human

Tested Applications: IHC.

Clonality: Monoclonal

Anti-Granzyme B (NK/T-Cell Lymphoma Marker) Antibody Clone: GZMB/2403

Clone GZMB/2403 Host and Isotype: Mouse IgG2b

Anti-Human Granzyme B (NK/T-Cell Lymphoma Marker) Positive Control Sample: A431 cells. Tonsil, Spleen or Hodgkin s Lymphoma

Cellular Localization of Antibody GZMB/2403 Staining: Cytoplasmic

Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.

Antibody Concentration: 200 ug/ml

Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.

Immunogen: Recombinant fragment of human GZMB protein (apprx. aa 73-187) (Please call for additional information.)

Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

Granzyme B (NK/T-Cell Lymphoma Marker) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, Granzyme B (NK/T-Cell Lymphoma Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Granzyme B (NK/T-Cell Lymphoma Marker) Ultraspecific Antibody Tested against >20,000 Human Proteins