Analysis of Protein Array containing more than 19,000 full-length human proteins using MSH6 Mouse Monoclonal Antibody (MSH6/2111) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing more than 19,000 full-length human proteins using MSH6 Mouse Monoclonal Antibody (MSH6/2111) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

MSH6 (DNA Mismatch Repair Protein) Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 199.00$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2956-MSM1
Species: Human
Tested Applications: ELISA, WB
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b, kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
2956-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
2956-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
2956-MSM1-P1ABX Size: 100 ug, Tag: Unconjugated $ 429.00
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SKU: 2956-MSM1-P0
MSH6 (DNA Mismatch Repair Protein) General Information
Alternate Names
DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC5; HSAP; MSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein
Molecular Weight
85kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol2956
Entrez Gene IDMSH6
UniProt ID(s)P52701
UniGene ID(s)Hs445052
COSMIC ID Link(s)MSH6
KEGG Gene ID(s)hsa:2956
General Description of MSH6 (DNA Mismatch Repair Protein).
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.

Human Anti-MSH6 (DNA Mismatch Repair Protein) Antibody Product Attributes

Species: Human
Tested Applications: ELISA, WB.
Clonality: Monoclonal
Anti-MSH6 (DNA Mismatch Repair Protein) Antibody Clone: MSH6/2111
Clone MSH6/2111 Host and Isotype: Mouse IgG2b, kappa
Anti-Human MSH6 (DNA Mismatch Repair Protein) Positive Control Sample: A431 or HeLa cells. Colon Carcinoma
Cellular Localization of Antibody MSH6/2111 Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human MSH6 protein (apprx. aa 374-540) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

MSH6 (DNA Mismatch Repair Protein) Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, MSH6 (DNA Mismatch Repair Protein) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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MSH6 (DNA Mismatch Repair Protein) Ultraspecific Antibody

Tested against >20,000 Human Proteins

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