Analysis of Protein Array containing >19,000 full-length human proteins using STAT3 Mouse Monoclonal Antibody (PCRP-STAT3-2F12). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Analysis of Protein Array containing >19,000 full-length human proteins using STAT3 Mouse Monoclonal Antibody (PCRP-STAT3-2F12). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

STAT3 / Signal Transducer and Activator of Transcription 3 Ultraspecific Antibody

Tested against >20,000 Human Proteins

$ 158.00$ 348.00
Please Select Product Options Below To View The Catalog Number.

SKU: 6774-MSM1
Species: Human
Tested Applications: ELISA
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a
Mass Spec Validated?: Not MS Validated

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Shipping Information
In Stock: 1-2 Day Lead Time.
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Datasheets and Documentation
Product Datasheet
SKU: 6774-MSM1-P0
STAT3 / Signal Transducer and Activator of Transcription 3 General Information
Alternate Names
APRF; HIES; ADMIO; ADMIO1
Molecular Weight
88kDa
Chromosomal Location
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol6774
Entrez Gene IDSTAT3
UniProt ID(s)P40763
UniGene ID(s)Hs463059
COSMIC ID Link(s)STAT3
KEGG Gene ID(s)hsa:6774
General Description of STAT3 / Signal Transducer and Activator of Transcription 3.
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

Human Anti-STAT3 / Signal Transducer and Activator of Transcription 3 Antibody Product Attributes

Species: Human
Tested Applications: ELISA.
Clonality: Monoclonal
Anti-STAT3 / Signal Transducer and Activator of Transcription 3 Antibody Clone: PCRP-STAT3-2F12
Clone PCRP-STAT3-2F12 Host and Isotype: Mouse IgG2a
Anti-Human STAT3 / Signal Transducer and Activator of Transcription 3 Positive Control Sample: A431 and Raji cells. Kidney, Brain or Heart
Cellular Localization of Antibody PCRP-STAT3-2F12 Staining: Cytoplasmic and Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human STAT3 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

STAT3 / Signal Transducer and Activator of Transcription 3 Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's product, STAT3 / Signal Transducer and Activator of Transcription 3 MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Tested against >20,000 Human Proteins

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STAT3 / Signal Transducer and Activator of Transcription 3 Ultraspecific Antibody

Tested against >20,000 Human Proteins

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