Recombinant Human CXCL12 / SDF-1 Protein

$ 108.00$ 278.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10218
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 96% as determined by SDS­PAGE and HPLC.
Length (Amino Acids): 99

Product NumberDescriptionPrice
QP10218-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 278.00
QP10218-ec-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 108.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10218-ec-10ug
Recombinant Human CXCL12 / SDF-1 Protein General Information
Alternate Names
CXCL12; SDF-1; SCYB12; IRH; PBSF; SDF1; TPAR1; TLSF
Curated Database and Bioinformatic Data
Gene SymbolCXCL12
Entrez Gene ID6387
Ensemble Gene IDENSG00000107562
RefSeq Protein Accession(s)NP_000600.1
RefSeq mRNA Accession(s)NM_000609.6, NM_001033886.2, NM_001178134.1, NM_001277990.1, NM_199168.3
UniProt ID(s)P48061
UniGene ID(s)Hs.522891
HGNC ID(s)HGNC:10672
COSMIC ID Link(s)CXCL12
KEGG Gene ID(s)hsa:6387
PharmGKB ID(s)PA35602
General Description of Recombinant Human CXCL12 / SDF-1 Protein.
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Human CXCL12 / SDF-1 Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant CXCL12 / SDF-1 based upon sequence from: Human
Host: QP10218 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human CXCL12 / SDF-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10218.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL­2 activated human peripheral blood T­lymphocytes is in a concentration range of 30­100 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKG RREEKVGKKE KIGKKKRQKK RKAAQKRKN
Purity: Greater than 96% as determined by SDS­PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human CXCL12 / SDF-1 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human CXCL12 / SDF-1 Protein

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