PDF DatasheetHuman IGF1 Isoform 2 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IGF1 Isoform 2 based upon sequence from: Human
Host: QP5347 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5347.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 10 ng/mL in the FDC-P1 cell proliferation assay. The bioactivity acceptance criteria is set at 1 .0 x 10^5 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IGF1 Isoform 2 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IGF1 Isoform 2 Protein (Animal Free) General Information | |
|---|---|
| Alternate Names | |
| IGF1, IGF-I, IGF-I, MGF, IGFI | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IGF1 |
| Entrez Gene ID | 3479 |
| Ensemble Gene ID | ENSG00000017427 |
| RefSeq Protein Accession(s) | NP_000609.1 |
| RefSeq mRNA Accession(s) | NM_000618.4, NM_001111284.1, NM_001111285.2 |
| UniProt ID(s) | P05019 |
| UniGene ID(s) | Hs.160562 |
| HGNC ID(s) | HGNC:5464 |
| COSMIC ID Link(s) | IGF1 |
| KEGG Gene ID(s) | hsa:3479 |
| PharmGKB ID(s) | PA29697 |
| General Description of Recombinant Human IGF1 Isoform 2 Protein (Animal Free). | |
| Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death. Mature human IGF-I is 100% homologous to bovine and porcine IGF-1 proteins. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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