C57Bl/6 splenocytes were stained with FITC Mouse Anti-NK1.1  and 0.06 ug APC Mouse Anti-KLRG1 (QAB74) (right panel) or 0.06 ug APC Golden Syrian Hamster IgG (left panel).

Mouse Anti-KLRG1 Antibody [2F1]

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Species: Mouse
Tested Applications: Flow Cytometry
Available Conjugates: FITC ;Unconjugated ;APC ;PE ;V450
Isotype: Golden Syrian Hamster IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB74-F-25ug
KLRG1 General Information
Alternate Names
MAFA-LIKE, MAFA-2F1, MAFA-L, 2F1, CLEC15A, MAFA, Killer cell lectin-like receptor subfamily G member
Curated Database and Bioinformatic Data
Gene SymbolKlrg1
Entrez Gene ID50928
Ensemble Gene IDENSMUSG00000030114
RefSeq Protein Accession(s)NP_058666
RefSeq mRNA Accession(s)NM_016970
RefSeq Genomic Accession(s)NC_000072
UniProt ID(s)O88713
UniGene ID(s)O88713
Cosmic ID(s)Klrg1
KEGG Gene ID(s)mmu:50928
General Description of KLRG1.
The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Mouse Anti-CD127 antibody (clone A7R34), for identification of effector T cell populations.

Mouse Anti-KLRG1 Antibody Product Attributes

Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-KLRG1 Antibody Clone: 2F1
Clone 2F1 Host and Isotype: Golden Syrian Hamster IgG
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 0.5 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

KLRG1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Staining with anti-KLRG1 antibody reveals KLRG1 expression is expected to be primarily localized to the vesicles.

Selected References

Thaventhiran JED, Hoffmann A, Magiera L, de la Roche M, Lingel H, Brunner-Weinzierl M, and Fearon DT. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry).Tessmer MS, Fugere C, Stevenaert F, Naidenko OV, Chong HJ, Leclercq G, and Brossay L. 2007. Int. Immunol. 19:391-400. (Immunoprecipitation, in vitro blocking, Flow cytometry)Robbins SH, Nguyen KB, Takahashi N, Mikayama T, Biron CA, and Brossay L. 2002. J. Immunol. 168: 2585-2589. (in vitro blocking)Hanke T, Corral L, Vance RE, and Raulet DH. 1998. Eur. J. Immunol. 28(12): 4409-4417. (Origination of 2F1 clone)

Limitations and Warranty

enQuire Bio's Mouse Anti-KLRG1 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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