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Recombinant Human TIR domain-containing adapter molecule 1 Protein

$ 1,708.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10006
Species: Human
Available Tags: Untagged
Host: Invitro-E.coli
Purity: Greater than 85% as determined by SDS-PAGE.
Length (Amino Acids): 712

Product NumberDescriptionPrice
QP10006-iv-100ug Size: 100 ug, Tag: Untagged (Native Protein)
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10006-iv-10ug
Recombinant Human TIR domain-containing adapter molecule 1 Protein General Information
Alternate Names
IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF
Curated Database and Bioinformatic Data
Gene SymbolTICAM1
Entrez Gene ID148022
Ensemble Gene IDENSG00000127666
RefSeq Protein Accession(s)NP_891549.1
RefSeq mRNA Accession(s)NM_182919.3
UniProt ID(s)Q8IUC6
UniGene ID(s)Hs.29344
HGNC ID(s)HGNC:18348
COSMIC ID Link(s)TICAM1
KEGG Gene ID(s)hsa:148022
PharmGKB ID(s)PA142670812
General Description of Recombinant Human TIR domain-containing adapter molecule 1 Protein.
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Human TIR domain-containing adapter molecule 1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant TIR domain-containing adapter molecule 1 based upon sequence from: Human
Host: QP10006 protein expressed in Invitro-E.coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TIR domain-containing adapter molecule 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10006.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Glu712
Amino Acid Sequence: MACTGPSLPS AFDILGAAGQ DKLLYLKHKL KTPRPGCQGQ DLLHAMVLLK LGQETEARIS LEALKADAVA RLVARQWAGV DSTEDPEEPP DVSWAVARLY HLLAEEKLCP ASLRDVAYQE AVRTLSSRDD HRLGELQDEA RNRCGWDIAG DPGSIRTLQS NLGCLPPSSA LPSGTRSLPR PIDGVSDWSQ GCSLRSTGSP ASLASNLEIS QSPTMPFLSL HRSPHGPSKL CDDPQASLVP EPVPGGCQEP EEMSWPPSGE IASPPELPSS PPPGLPEVAP DATSTGLPDT PAAPETSTNY PVECTEGSAG PQSLPLPILE PVKNPCSVKD QTPLQLSVED TTSPNTKPCP PTPTTPETSP PPPPPPPSST PCSAHLTPSS LFPSSLESSS EQKFYNFVIL HARADEHIAL RVREKLEALG VPDGATFCED FQVPGRGELS CLQDAIDHSA FIILLLTSNF DCRLSLHQVN QAMMSNLTRQ GSPDCVIPFL PLESSPAQLS SDTASLLSGL VRLDEHSQIF ARKVANTFKP HRLQARKAMW RKEQDTRALR EQSQHLDGER MQAAALNAAY SAYLQSYLSY QAQMEQLQVA FGSHMSFGTG APYGARMPFG GQVPLGAPPP FPTWPGCPQP PPLHAWQAGT PPPPSPQPAA FPQSLPFPQS PAFPTASPAP PQSPGLQPLI IHHAQMVQLG LNNHMWNQRG SQAPEDKTQE AE
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TIR domain-containing adapter molecule 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human TIR domain-containing adapter molecule 1 Protein