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Recombinant Human Thioredoxin-interacting Protein

$ 1,388.00
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SKU: QP10023
Species: Human
Available Tags: His-SUMO
Host: Invitro-E.coli
Purity: Greater than 85% as determined by SDS-PAGE.
Length (Amino Acids): 391

Product NumberDescriptionPrice
QP10023-iv-100ug Size: 100 ug, Tag: His-SUMO
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10023-iv-10ug
Recombinant Human Thioredoxin-interacting protein Protein General Information
Alternate Names
THIF; ARRDC6; HHCPA78; EST01027; VDUP1
Curated Database and Bioinformatic Data
Gene SymbolTxnip
Entrez Gene ID10628
Ensemble Gene IDENSG00000265972
RefSeq Protein Accession(s)NP_001300901.1
RefSeq mRNA Accession(s)NM_001313972.1, NM_006472.5
UniProt ID(s)Q9H3M7
UniGene ID(s)Hs.533977
HGNC ID(s)HGNC:16952
COSMIC ID Link(s)Txnip
KEGG Gene ID(s)hsa:10628
PharmGKB ID(s)PA38194
General Description of Recombinant Human Thioredoxin-interacting protein Protein.
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Human Thioredoxin-interacting protein Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Thioredoxin-interacting protein based upon sequence from: Human
Host: QP10023 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) Thioredoxin-interacting protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10023.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Gln391
Amino Acid Sequence: MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG VAKVLWMQGS QQCKQTSEYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK FGFELPQGPL GTSFKGKYGC VDYWVKAFLD RPSQPTQETK KNFEVVDLVD VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV SARIDRKGFC EGDEISIHAD FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN HIISGTCASW RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDVIPE DHRLESPTTP LLDDMDGSQD SPIFMYAPEF KFMPPPTYTE VDPCILNNNV Q
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Thioredoxin-interacting protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Thioredoxin-interacting Protein