SDS-PAGE separation of QP1078 followed by commassie total protein stain results in a primary band consistent with reported data for Fragile histidine triad / FHIT. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Fragile histidine triad / FHIT Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP1078
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 146

Product Number	Description	Price
QP1078-ec-100ug	Size: 100 ug, Tag: His	$ 398.00
QP1078-ec-1mg	Size: 1 mg, Tag: His	$ 1,728.00

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2-4 weeks

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP1078-ec-10ug

Recombinant Human Fragile histidine triad / FHIT Protein General Information
Curated Database and Bioinformatic Data
Gene Symbol	FHIT
Entrez Gene ID	2272
Ensemble Gene ID	ENSG00000189283
RefSeq Protein Accession(s)	NP_001159715.1
RefSeq mRNA Accession(s)	NM_001166243.2, NM_001320899.1, NM_001320900.1, NM_002012.3
UniProt ID(s)	P49789
UniGene ID(s)	Hs.655995
HGNC ID(s)	HGNC:3701
COSMIC ID Link(s)	FHIT
KEGG Gene ID(s)	hsa:2272
PharmGKB ID(s)	PA28140
General Description of Recombinant Human Fragile histidine triad / FHIT Protein.
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extrely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor

Human Fragile histidine triad / FHIT Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant Fragile histidine triad / FHIT based upon sequence from Human

Host: QP1078 protein expressed in E. coli.

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Fragile histidine triad / FHIT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.

Application Notes: Please contact us for application specific information for QP1078.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Ser2 - Gln147

Amino Acid Sequence: SFRFGQHLIK PSVVFLKTEL SFALVNRKPV VPGHVLVCPL RPVERFHDLR PDEVADLFQT TQRVGTVVEK HFHGTSLTFS MQDGPEAGQT VKHVHVHVLP RKAGDFHRND SIYEELQKHD KEDFPASWRS EEEMAAEAAA LRVYFQ

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.

Concentration of Human Fragile histidine triad / FHIT Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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