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Recombinant Human Apoptosis-inducing factor 1, mitochondrial Protein

$ 398.00$ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5633
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 510

Product NumberDescriptionPrice
QP5633-ec-100ug Size: 100 ug, Tag: His-SUMO $ 398.00
QP5633-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,728.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP5633-ec-10ug
Recombinant Human Apoptosis-inducing factor 1, mitochondrial Protein General Information
Alternate Names
COXPD6, DFNX5, PDCD8, NAMSD, AIF, COWCK, CMT2D, CMTX4, NADMR
Curated Database and Bioinformatic Data
Gene SymbolAIFM1
Entrez Gene ID9131
Ensemble Gene IDENSG00000156709
RefSeq Protein Accession(s)NP_001124318.2
RefSeq mRNA Accession(s)NM_001130846.3, NM_001130847.3, NM_004208.3, NM_145812.2
UniProt ID(s)O95831
UniGene ID(s)Hs.424932
HGNC ID(s)HGNC:8768
COSMIC ID Link(s)AIFM1
KEGG Gene ID(s)hsa:9131
PharmGKB ID(s)PA162376129
General Description of Recombinant Human Apoptosis-inducing factor 1, mitochondrial Protein.
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermbrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

Human Apoptosis-inducing factor 1, mitochondrial Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Apoptosis-inducing factor 1, mitochondrial based upon sequence from Human
Host: QP5633 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Apoptosis-inducing factor 1, mitochondrial, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5633.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly103 - Glu612
Amino Acid Sequence: GLTPEQKQKK AALSASEGEE VPQDKAPSHV PFLLIGGGTA AFAAARSIRA RDPGARVLIV SEDPELPYMR PPLSKELWFS DDPNVTKTLR FKQWNGKERS IYFQPPSFYV SAQDLPHIEN GGVAVLTGKK VVQLDVRDNM VKLNDGSQIT YEKCLIATGG TPRSLSAIDR AGAEVKSRTT LFRKIGDFRS LEKISREVKS ITIIGGGFLG SELACALGRK ARALGTEVIQ LFPEKGNMGK ILPEYLSNWT MEKVRREGVK VMPNAIVQSV GVSSGKLLIK LKDGRKVETD HIVAAVGLEP NVELAKTGGL EIDSDFGGFR VNAELQARSN IWVAGDAACF YDIKLGRRRV EHHDHAVVSG RLAGENMTGA AKPYWHQSMF WSDLGPDVGY EAIGLVDSSL PTVGVFAKAT AQDNPKSATE QSGTGIRSES ETESEASEIT IPPSTPAVPQ APVQGEDYGK GVIFYLRDKV VVGIVLWNIF NRMPIARKII KDGEQHEDLN EVAKLFNIHE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Apoptosis-inducing factor 1, mitochondrial Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Apoptosis-inducing factor 1, mitochondrial Protein