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Recombinant Human BCL2L1 / Bcl-XL Protein

$ 398.00 – $ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5711
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 209

Product NumberDescriptionPrice
QP5711-ec-100ug Size: 100 ug, Tag: His-SUMO $ 398.00
QP5711-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,728.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP5711-ec-10ug
Recombinant Human BCL2L1 / Bcl-XL Protein General Information
Alternate Names
BCL2L1, Bcl-XL, BclX, bcl2-L-1, Bcl(X)L, Bcl2l, Bcl-XL, bcl-x
Curated Database and Bioinformatic Data
Gene SymbolBCL2L1
Entrez Gene ID598
Ensemble Gene IDENSG00000171552
RefSeq Protein Accession(s)NP_001182.1
RefSeq mRNA Accession(s)NM_001191.3, NM_001317919.1, NM_001317920.1, NM_001317921.1, NM_001322239.1, NM_001322240.1, NM_001322242.1, NM_138578.2, XM_011528964.2, XM_017027993.1
UniProt ID(s)Q07817
UniGene ID(s)Hs.516966
HGNC ID(s)HGNC:992
COSMIC ID Link(s)BCL2L1
KEGG Gene ID(s)hsa:598
PharmGKB ID(s)PA76
General Description of Recombinant Human BCL2L1 / Bcl-XL Protein.
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial mbrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial mbrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis.

Human BCL2L1 / Bcl-XL Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant BCL2L1 / Bcl-XL based upon sequence from Human
Host: QP5711 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) BCL2L1 / Bcl-XL, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5711.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - Arg209
Amino Acid Sequence: MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGWDT FVELYGNNAA AESRKGQER
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human BCL2L1 / Bcl-XL Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human BCL2L1 / Bcl-XL Protein