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SDS-PAGE separation of QP5727 followed by commassie total protein stain results in a primary band consistent with reported data for Lys-63-specific deubiquitinase BRCC36. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP5727 followed by commassie total protein stain results in a primary band consistent with reported data for Lys-63-specific deubiquitinase BRCC36. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Lys-63-specific deubiquitinase BRCC36 Protein

$ 398.00 – $ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5727
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 315

Product NumberDescriptionPrice
QP5727-ec-100ug Size: 100 ug, Tag: GST $ 448.00
QP5727-ec-1mg Size: 1 mg, Tag: GST $ 1,938.00
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1-2 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP5727-ec-10ug
Recombinant Human Lys-63-specific deubiquitinase BRCC36 Protein General Information
Alternate Names
C6.1A, BRCC36, CXorf53
Curated Database and Bioinformatic Data
Gene SymbolBRCC3
Entrez Gene ID79184
Ensemble Gene IDENSG00000185515
RefSeq Protein Accession(s)NP_001018065.1
RefSeq mRNA Accession(s)NM_001018055.2, NM_001242640.1, NM_024332.3, XM_017029838.1
UniProt ID(s)P46736
UniGene ID(s)Hs.558537
HGNC ID(s)HGNC:24185
COSMIC ID Link(s)BRCC3
KEGG Gene ID(s)hsa:79184
PharmGKB ID(s)PA134922847
General Description of Recombinant Human Lys-63-specific deubiquitinase BRCC36 Protein.
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically roves 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex

Human Lys-63-specific deubiquitinase BRCC36 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Lys-63-specific deubiquitinase BRCC36 based upon sequence from Human
Host: QP5727 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Lys-63-specific deubiquitinase BRCC36, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5727.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 - Glu316
Amino Acid Sequence: AVQVVQAVQA VHLESDAFLV CLNHALSTEK EEVMGLCIGE LNDDTRSDSK FAYTGTEMRT VAEKVDAVRI VHIHSVIILR RSDKRKDRVE ISPEQLSAAS TEAERLAELT GRPMRVVGWY HSHPHITVWP SHVDVRTQAM YQMMDQGFVG LIFSCFIEDK NTKTGRVLYT CFQSIQAQKS SESLHGPRDF WSSSQHISIE GQKEEERYER IEIPIHIVPH VTIGKVCLES AVELPKILCQ EEQDAYRRIH SLTHLDSVTK IHNGSVFTKN LCSQMSAVSG PLLQWLEDRL EQNQQHLQEL QQEKEELMQE LSSLE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Lys-63-specific deubiquitinase BRCC36 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Lys-63-specific deubiquitinase BRCC36 Protein

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