PDF DatasheetHuman G1 / S-specific cyclin-D2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant G1 / S-specific cyclin-D2 based upon sequence from Human
Host: QP5777 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) G1/S-specific cyclin-D2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5777.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human G1 / S-specific cyclin-D2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human G1 / S-specific cyclin-D2 Protein General Information | |
|---|---|
| Alternate Names | |
| MPPH3, KIAK0002 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCND2 |
| Entrez Gene ID | 894 |
| Ensemble Gene ID | ENSG00000118971 |
| RefSeq Protein Accession(s) | NP_001750.1 |
| RefSeq mRNA Accession(s) | NM_001759.3 |
| UniProt ID(s) | P30279 |
| UniGene ID(s) | Hs.376071 |
| HGNC ID(s) | HGNC:1583 |
| COSMIC ID Link(s) | CCND2 |
| KEGG Gene ID(s) | hsa:894 |
| PharmGKB ID(s) | PA26150 |
| General Description of Recombinant Human G1 / S-specific cyclin-D2 Protein. | |
| Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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