SDS-PAGE separation of QP5777 followed by commassie total protein stain results in a primary band consistent with reported data for G1 / S-specific cyclin-D2. These data demonstrate Greater than 80% as determined by SDS-PAGE.
SDS-PAGE separation of QP5777 followed by commassie total protein stain results in a primary band consistent with reported data for G1 / S-specific cyclin-D2. These data demonstrate Greater than 80% as determined by SDS-PAGE.

Recombinant Human G1 / S-specific cyclin-D2 Protein

$ 448.00$ 1,938.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5777
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: GST
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 290

Product NumberDescriptionPrice
QP5777-ec-100ug Size: 100 ug, Tag: GST $ 448.00
QP5777-ec-1mg Size: 1 mg, Tag: GST $ 1,938.00
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2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Bioactivity (test results eg. IU/ml):


SKU: QP5777-ec-10ug
Recombinant Human G1 / S-specific cyclin-D2 Protein General Information
Alternate Names
MPPH3, KIAK0002
Curated Database and Bioinformatic Data
Gene SymbolCCND2
Entrez Gene ID894
Ensemble Gene IDENSG00000118971
RefSeq Protein Accession(s)NP_001750.1
RefSeq mRNA Accession(s)NM_001759.3
UniProt ID(s)P30279
UniGene ID(s)Hs.376071
HGNC ID(s)HGNC:1583
COSMIC ID Link(s)CCND2
KEGG Gene ID(s)hsa:894
PharmGKB ID(s)PA26150
General Description of Recombinant Human G1 / S-specific cyclin-D2 Protein.
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex

Human G1 / S-specific cyclin-D2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant G1 / S-specific cyclin-D2 based upon sequence from Human
Host: QP5777 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) G1/S-specific cyclin-D2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5777.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human G1 / S-specific cyclin-D2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human G1 / S-specific cyclin-D2 Protein

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