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Recombinant Human G1 / S-specific cyclin-D3 Protein

$ 648.00$ 2,768.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5778
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: GST
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 293

Product NumberDescriptionPrice
QP5778-ec-100ug Size: 100 ug, Tag: GST $ 648.00
QP5778-ec-1mg Size: 1 mg, Tag: GST $ 2,768.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP5778-ec-10ug
Recombinant Human G1 / S-specific cyclin-D3 Protein General Information
Curated Database and Bioinformatic Data
Gene SymbolCCND3
Entrez Gene ID896
Ensemble Gene IDENSG00000112576
RefSeq Protein Accession(s)NP_001129489.1
RefSeq mRNA Accession(s)NM_001136017.3, NM_001136125.2, NM_001136126.2, NM_001287427.1, NM_001287434.1, NM_001760.4
UniProt ID(s)P30281
UniGene ID(s)Hs.534307
HGNC ID(s)HGNC:1585
COSMIC ID Link(s)CCND3
KEGG Gene ID(s)hsa:896
PharmGKB ID(s)PA26152
General Description of Recombinant Human G1 / S-specific cyclin-D3 Protein.
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Human G1 / S-specific cyclin-D3 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant G1 / S-specific cyclin-D3 based upon sequence from Human
Host: QP5778 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) G1/S-specific cyclin-D3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5778.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MELLCCEGTR HAPRAGPDPR LLGDQRVLQS LLRLEERYVP RASYFQCVQR EIKPHMRKML AYWMLEVCEE QRCEEEVFPL AMNYLDRYLS CVPTRKAQLQ LLGAVCMLLA SKLRETTPLT IEKLCIYTDH AVSPRQLRDW EVLVLGKLKW DLAAVIAHDF LAFILHRLSL PRDRQALVKK HAQTFLALCA TDYTFAMYPP SMIATGSIGA AVQGLGACSM SGDELTELLA GITGTEVDCL RACQEQIEAA LRESLREASQ TSSSPAPKAP RGSSSQGPSQ TSTPTDVTAI HL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human G1 / S-specific cyclin-D3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human G1 / S-specific cyclin-D3 Protein