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SDS-PAGE separation of QP5875 followed by commassie total protein stain results in a primary band consistent with reported data for CSF1R / MCSF Receptor / CD115. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP5875 followed by commassie total protein stain results in a primary band consistent with reported data for CSF1R / MCSF Receptor / CD115. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Cat CSF1R / MCSF Receptor / CD115 Protein

$ 728.00 – $ 2,468.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP5875
Species: Cat
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 495

Product NumberDescriptionPrice
QP5875-ec-100ug Size: 100 ug, Tag: His-SUMO $ 728.00
QP5875-ec-1mg Size: 1 mg, Tag: His-SUMO $ 2,468.00
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2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP5875-ec-10ug
Recombinant Feline CSF1R / MCSF Receptor / CD115 Protein General Information
Alternate Names
CSF1R, MCSF Receptor, CD115, C-FMS, HDLS, CSF-1R, FMS, CSFR, FIM2, M-CSF-R, CD115
Curated Database and Bioinformatic Data
Gene SymbolCSF1R
Entrez Gene ID493706
RefSeq Protein Accession(s)NP_001009231.1
RefSeq mRNA Accession(s)NM_001009231.1
UniProt ID(s)P13369
COSMIC ID Link(s)CSF1R
KEGG Gene ID(s)fca:493706
General Description of Recombinant Feline CSF1R / MCSF Receptor / CD115 Protein.
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hatopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and fale fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of mbrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family mbers, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family mbers STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor .

Cat CSF1R / MCSF Receptor / CD115 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant CSF1R / MCSF Receptor / CD115 based upon sequence from Cat
Host: QP5875 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Felis catus (Cat) (Felis silvestris catus) CSF1R / MCSF Receptor / CD115, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5875.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Val20 - Pro5
Amino Acid Sequence: VPVIQPSGPE LVVEPGTTVT LRCVGNGSVE WDGPISPHWN LDLDPPSSIL TTNNATFQNT GTYHCTEPGN PQGGNATIHL YVKDPARPWK VLAQEVTVLE GQDALLPCLL TDPALEAGVS LVRVRGRPVL RQTNYSFSPW HGFTIHKAKF IENHVYQCSA RVDGRTVTSM GIWLKVQKDI SGPATLTLEP AELVRIQGEA AQIVCSASNI DVNFDVSLRH GDTKLTISQQ SDFHDNRYQK VLTLNLDHVS FQDAGNYSCT ATNAWGNHSA SMVFRVVESA YLNLTSEQSL LQEVTVGEKV DLQVKVEAYP GLESFNWTYL GPFSDYQDKL DFVTIKDTYR YTSTLSLPRL KRSEAGRYSF LARNAGGQNA LTFELTLRYP PEVRVTMTLI NGSDTLLCEA SGYPQPSVTW VQCRSHTDRC DESAGLVLED SHSEVLSQVP FHEVIVHSLL AIGTLEHNRT YECRAFNSVG NSSQTFWPIS IGAHTQLPDE LLFTP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Cat CSF1R / MCSF Receptor / CD115 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Cat CSF1R / MCSF Receptor / CD115 Protein

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