SDS-PAGE separation of QP6338 followed by commassie total protein stain results in a primary band consistent with reported data for MKK6 / MEK6 / MAP2K6. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP6338 followed by commassie total protein stain results in a primary band consistent with reported data for MKK6 / MEK6 / MAP2K6. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human MKK6 / MEK6 / MAP2K6 Protein

$ 448.00$ 1,938.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6338
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO, His
Host: Baculovirus, E.coli.
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 334

Product NumberDescriptionPrice
QP6338-ec-100ug Size: 100 ug, Tag: His-SUMO $ 448.00
QP6338-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,938.00
QP6338-ba-20ug Size: 20 ug, Tag: His $ 448.00
QP6338-ba-100ug Size: 100 ug, Tag: His $ 1,258.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP6338-ec-10ug
Recombinant Human MKK6 / MEK6 / MAP2K6 Protein General Information
Alternate Names
MKK6, MEK6, MAP2K6, SAPKK3, MKK6, SAPKK-3, MAPKK6, MEK6, PRKMK6
Curated Database and Bioinformatic Data
Gene SymbolMAP2K6
Entrez Gene ID5608
Ensemble Gene IDENSG00000108984
RefSeq Protein Accession(s)NP_002749.2
RefSeq mRNA Accession(s)NM_002758.3
UniProt ID(s)P52564
UniGene ID(s)Hs.463978
HGNC ID(s)HGNC:6846
COSMIC ID Link(s)MAP2K6
KEGG Gene ID(s)hsa:5608
PharmGKB ID(s)PA30591
General Description of Recombinant Human MKK6 / MEK6 / MAP2K6 Protein.
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases

Human MKK6 / MEK6 / MAP2K6 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant MKK6 / MEK6 / MAP2K6 based upon sequence from Human
Host: QP6338 protein expressed in Baculovirus, E.coli..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) MKK6 / MEK6 / MAP2K6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6338.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Asp334
Amino Acid Sequence: MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV KPSNVLINAL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human MKK6 / MEK6 / MAP2K6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human MKK6 / MEK6 / MAP2K6 Protein

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