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Recombinant Human E3 ubiquitin-protein ligase RBX1 Protein

$ 578.00$ 2,468.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6590
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: GST
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 109

Product NumberDescriptionPrice
QP6590-ec-100ug Size: 100 ug, Tag: GST $ 578.00
QP6590-ec-1mg Size: 1 mg, Tag: GST $ 2,468.00
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2-4 weeks
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Datasheets and Documentation
Product Datasheet
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Reconsitution Instructions (Leave Blank if Liquid):

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Bioactivity (test results eg. IU/ml):


SKU: QP6590-ec-10ug
Recombinant Human E3 ubiquitin-protein ligase RBX1 Protein General Information
Alternate Names
RNF75, BA554C12.1, ROC1
Curated Database and Bioinformatic Data
Gene SymbolRBX1
Entrez Gene ID9978
Ensemble Gene IDENSG00000100387
RefSeq Protein Accession(s)NP_055063.1
RefSeq mRNA Accession(s)NM_014248.3
UniProt ID(s)P62877
UniGene ID(s)Hs.474949
HGNC ID(s)HGNC:9928
COSMIC ID Link(s)RBX1
KEGG Gene ID(s)hsa:9978
PharmGKB ID(s)PA34299
General Description of Recombinant Human E3 ubiquitin-protein ligase RBX1 Protein.
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

Human E3 ubiquitin-protein ligase RBX1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase RBX1 based upon sequence from Human
Host: QP6590 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase RBX1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6590.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEFQKYGH
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human E3 ubiquitin-protein ligase RBX1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human E3 ubiquitin-protein ligase RBX1 Protein