SDS-PAGE separation of QP6609 followed by commassie total protein stain results in a primary band consistent with reported data for RIPK2. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP6609 followed by commassie total protein stain results in a primary band consistent with reported data for RIPK2. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human RIPK2 Protein

$ 398.00$ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6609
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 540

Product NumberDescriptionPrice
QP6609-ec-100ug Size: 100 ug, Tag: His $ 398.00
QP6609-ec-1mg Size: 1 mg, Tag: His $ 1,728.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP6609-ec-10ug
Recombinant Human RIPK2 Protein General Information
Alternate Names
RICK, CARD3, CARDIAK, GIG30, RIP2, CCK, Receptor-interacting serine/threonine-protein kinase
Curated Database and Bioinformatic Data
Gene SymbolRIPK2
Entrez Gene ID8767
Ensemble Gene IDENSG00000104312
RefSeq Protein Accession(s)NP_003812.1
RefSeq mRNA Accession(s)NM_003821.5, XM_005251092.3
UniProt ID(s)O43353
UniGene ID(s)Hs.103755
HGNC ID(s)HGNC:10020
COSMIC ID Link(s)RIPK2
KEGG Gene ID(s)hsa:8767
PharmGKB ID(s)PA34395
General Description of Recombinant Human RIPK2 Protein.
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagent of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Human RIPK2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant RIPK2 based upon sequence from Human
Host: QP6609 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) RIPK2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6609.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Met540
Amino Acid Sequence: MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human RIPK2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human RIPK2 Protein

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