SEQUEST analysis of LC MS/MS spectra obtained from a run with QP6616 identified a match between this protein and the spectra of a peptide sequence that matches a region of Nuclear receptor ROR-gamma.
SEQUEST analysis of LC MS/MS spectra obtained from a run with QP6616 identified a match between this protein and the spectra of a peptide sequence that matches a region of Nuclear receptor ROR-gamma.Additional SEQUEST analysis of the LC MS/MS spectra from QP6616 identified an additional between this protein and the spectra of another peptide sequence that matches a region of Nuclear receptor ROR-gamma confirming successful recombinant synthesis.

Recombinant Human Nuclear receptor ROR-gamma Protein

$ 398.00$ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6616
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 518

Product NumberDescriptionPrice
QP6616-ec-100ug Size: 100 ug, Tag: His-SUMO $ 448.00
QP6616-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,938.00
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1-2 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP6616-ec-10ug
Recombinant Human Nuclear receptor ROR-gamma Protein General Information
Alternate Names
RZRG, TOR, NR1F3, RORG, IMD42, RZR-GAMMA
Curated Database and Bioinformatic Data
Gene SymbolRORC
Entrez Gene ID6097
Ensemble Gene IDENSG00000143365
RefSeq Protein Accession(s)NP_001001523.1
RefSeq mRNA Accession(s)NM_001001523.1, NM_005060.3
UniProt ID(s)P51449
UniGene ID(s)Hs.256022
HGNC ID(s)HGNC:10260
COSMIC ID Link(s)RORC
KEGG Gene ID(s)hsa:6097
PharmGKB ID(s)PA34632
General Description of Recombinant Human Nuclear receptor ROR-gamma Protein.
Nuclear receptor that binds DNA as a monomer to ROR response elents (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response elent on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1. Regulates the rhythmic expression of PROX1 and promotes its nuclear localization .

Human Nuclear receptor ROR-gamma Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Nuclear receptor ROR-gamma based upon sequence from Human
Host: QP6616 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Nuclear receptor ROR-gamma, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6616.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Lys518
Amino Acid Sequence: MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQR CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS GSGPSYSNNL AKAGLNGASC HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV ERLQIFQHLH PIVVQAAFPP LYKELFSTET ESPVGLSK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Nuclear receptor ROR-gamma Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Nuclear receptor ROR-gamma Protein

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