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Recombinant Human Serine / arginine-rich splicing factor 1 Protein

$ 398.00 – $ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP6679
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 247

Product NumberDescriptionPrice
QP6679-ec-100ug Size: 100 ug, Tag: His-SUMO $ 398.00
QP6679-ec-1mg Size: 1 mg, Tag: His-SUMO $ 1,728.00
Shipping Information
2-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP6679-ec-10ug
Recombinant Human Serine / arginine-rich splicing factor 1 Protein General Information
Alternate Names
SFRS1, SRp30a, ASF, SF2, SF2p33
Curated Database and Bioinformatic Data
Gene SymbolSRSF1
Entrez Gene ID6426
Ensemble Gene IDENSG00000136450
RefSeq Protein Accession(s)NP_001071634.1
RefSeq mRNA Accession(s)NM_001078166.1, NM_006924.4
UniProt ID(s)Q07955
UniGene ID(s)Hs.68714
HGNC ID(s)HGNC:10780
COSMIC ID Link(s)SRSF1
KEGG Gene ID(s)hsa:6426
PharmGKB ID(s)PA35696
General Description of Recombinant Human Serine / arginine-rich splicing factor 1 Protein.
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

Human Serine / arginine-rich splicing factor 1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Serine / arginine-rich splicing factor 1 based upon sequence from Human
Host: QP6679 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Serine/arginine-rich splicing factor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6679.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 - Thr248
Amino Acid Sequence: SGGGVIRGPA GNNDCRIYVG NLPPDIRTKD IEDVFYKYGA IRDIDLKNRR GGPPFAFVEF EDPRDAEDAV YGRDGYDYDG YRLRVEFPRS GRGTGRGGGG GGGGGAPRGR YGPPSRRSEN RVVVSGLPPS GSWQDLKDHM REAGDVCYAD VYRDGTGVVE FVRKEDMTYA VRKLDNTKFR SHEGETAYIR VKVDGPRSPS YGRSRSRSRS RSRSRSRSNS RSRSYSPRRS RGSPRYSPRH SRSRSRT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Serine / arginine-rich splicing factor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Serine / arginine-rich splicing factor 1 Protein