SDS-PAGE separation of QP7409 followed by commassie total protein stain results in a primary band consistent with reported data for Protein E6. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Protein E6

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP7409
Species: Human
Available Tags: His
Host: E.coli, Yeast.
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 158

Product Number	Description	Price
QP7409-ec-100ug	Size: 100 ug, Tag: His	$ 398.00
QP7409-ec-1mg	Size: 1 mg, Tag: His	$ 1,728.00
QP7409-ye-100ug	Size: 100 ug, Tag: His	$ 468.00
QP7409-ye-500ug	Size: 500 ug, Tag: His	$ 1,298.00

Shipping Information

7-10 days

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP7409-ec-10ug

Recombinant Human Protein E6 Protein General Information
Alternate Names
HpV16gp1
Curated Database and Bioinformatic Data
Gene Symbol	E6
Entrez Gene ID	1489078
RefSeq Protein Accession(s)	NP_041325.1
RefSeq mRNA Accession(s)	NC_001526.4
UniProt ID(s)	P03126
KEGG Gene ID(s)	vg:1489078
General Description of Recombinant Human Protein E6 Protein.
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting th to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Human Protein E6 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant Protein E6 based on published sequence from: Human

Host: QP7409 protein expressed in E.coli, Yeast.

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein E6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP7409.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Met1 - Leu158

Amino Acid Sequence: MHQKRTAMFQ DPQERPRKLP QLCTELQTTI HDIILECVYC KQQLLRREVY DFAFRDLCIV YRDGNPYAVC DKCLKFYSKI SEYRHYCYSL YGTTLEQQYN KPLCDLLIRC INCQKPLCPE EKQRHLDKKQ RFHNIRGRWT GRCMSCCRSS RTRRETQL

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human Protein E6 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

There are no reviews yet.