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Recombinant Human ATG14 Protein

$ 398.00$ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP7740
Species: Human
Available Tags: His-Myc
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 492

Product NumberDescriptionPrice
QP7740-ec-100ug Size: 100 ug, Tag: His-Myc $ 398.00
QP7740-ec-1mg Size: 1 mg, Tag: His-Myc $ 1,728.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP7740-ec-10ug
Recombinant Human ATG14 Protein General Information
Alternate Names
KIAA0831; ATG14L; BARKOR; Beclin 1-associated autophagy-related key regulat
Curated Database and Bioinformatic Data
Gene SymbolATG14
Entrez Gene ID22863
Ensemble Gene IDENSG00000126775
RefSeq Protein Accession(s)NP_055739.2
RefSeq mRNA Accession(s)NM_014924.4, XM_011536563.2
UniProt ID(s)Q6ZNE5
UniGene ID(s)Hs.414809
HGNC ID(s)HGNC:19962
COSMIC ID Link(s)ATG14
KEGG Gene ID(s)hsa:22863
PharmGKB ID(s)PA165478560
General Description of Recombinant Human ATG14 Protein.
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).

Human ATG14 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant ATG14 based upon sequence from: Human
Host: QP7740 protein expressed in E. coli.
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ATG14, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7740.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Arg492
Amino Acid Sequence: MASPSGKGAR ALEAPGCGPR PLARDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ SGDFVYFDGR DRERFIDKKE RLSRLKSKQE EFQKEVLKAM EGKWITDQLR WKIMSCKMRI EQLKQTICKG NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT IDLRSHYERL ANLRRSHILE LTSVIFPIEE VKTGVRDPAD VSSESDSAMT SSTVSKLAEA RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY SWVEEKKTTQ GPDMEQSNPA YTISAALCYA TQLVNILSHI LDVNLPKKLC NSEFCGENLS KQKFTRAVKK LNANILYLCF SQHVNLDQLQ PLHTLRNLMY LVSPSSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDESG DERVSDEETD LGTDWENLPS PRFCDIPSQS VEVSQSQSTQ ASPPIASSSA GGMISSAAAS VTSWFKAYTG HR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ATG14 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human ATG14 Protein