enQuire Bio » Products » Recombinant Protein » Recombinant Human IFIH1 Protein
SEQUEST analysis of LC MS/MS spectra obtained from a run with QP8166 identified a match between this protein and the spectra of a peptide sequence that matches a region of IFIH1.
SEQUEST analysis of LC MS/MS spectra obtained from a run with QP8166 identified a match between this protein and the spectra of a peptide sequence that matches a region of IFIH1.Additional SEQUEST analysis of the LC MS/MS spectra from QP8166 identified an additional between this protein and the spectra of another peptide sequence that matches a region of IFIH1 confirming successful recombinant synthesis.SDS-PAGE separation of QP8166 followed by commassie total protein stain results in a primary band consistent with reported data for IFIH1. These data demonstrate Greater than 80% as determined by SDS-PAGE.

Recombinant Human IFIH1 Protein

$ 578.00 – $ 2,468.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8166
Species: Human
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 326

Product NumberDescriptionPrice
QP8166-ec-100ug Size: 100 ug, Tag: His-SUMO $ 578.00
QP8166-ec-1mg Size: 1 mg, Tag: His-SUMO $ 2,468.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8166-ec-10ug
Recombinant Human IFIH1 Protein General Information
Alternate Names
AGS7; MDA-5; MDA5; RLR-2; IDDM19; Hlcd; SGMRT1; Interferon-induced helicase C domain-containing protein
Curated Database and Bioinformatic Data
Gene SymbolIFIH1
Entrez Gene ID64135
Ensemble Gene IDENSG00000115267
RefSeq Protein Accession(s)NP_071451.2
RefSeq mRNA Accession(s)NM_022168.3
UniProt ID(s)Q9BYX4
UniGene ID(s)Hs.163173
HGNC ID(s)HGNC:18873
COSMIC ID Link(s)IFIH1
KEGG Gene ID(s)hsa:64135
PharmGKB ID(s)PA134889215
General Description of Recombinant Human IFIH1 Protein.
Innate immune receptor which acts as a Cytoplasmic domain sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Human IFIH1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant IFIH1 based upon sequence from: Human
Host: QP8166 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) IFIH1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8166.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Lys700 - Asp1025
Amino Acid Sequence: KLTKLRNTIM EQYTRTEESA RGIIFTKTRQ SAYALSQWIT ENEKFAEVGV KAHHLIGAGH SSEFKPMTQN EQKEVISKFR TGKINLLIAT TVAEEGLDIK ECNIVIRYGL VTNEIAMVQA RGRARADEST YVLVAHSGSG VIEHETVNDF REKMMYKAIH CVQNMKPEEY AHKILELQMQ SIMEKKMKTK RNIAKHYKNN PSLITFLCKN CSVLACSGED IHVIEKMHHV NMTPEFKELY IVRENKALQK KCADYQINGE IICKCGQAWG TMMVHKGLDL PCLKIRNFVV VFKNNSTKKQ YKKWVELPIT FPNLDYSECC LFSDED
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IFIH1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human IFIH1 Protein

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