SDS-PAGE separation of QP8357 followed by commassie total protein stain results in a primary band consistent with reported data for Dynein light chain 1

Recombinant Human Dynein light chain 1, cytoplasmic Protein

$ 148.00$ 1,678.00
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SKU: QP8357
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 89

Size
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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8357-ec-10ug
Recombinant Human Dynein light chain 1, cytoplasmic Protein General Information
Alternate Names
DNCLC1; LC8a; PIN; DLC1; DNCL1; hdlc1; DLC8; LC8
Curated Database and Bioinformatic Data
Gene SymbolDYNLL1
Entrez Gene ID8655
Ensemble Gene IDENSG00000088986
RefSeq Protein Accession(s)NP_001032583.1
RefSeq mRNA Accession(s)NM_001037494.1, NM_001037495.1, NM_003746.2
UniProt ID(s)P63167
UniGene ID(s)Hs.5120
HGNC ID(s)HGNC:15476
COSMIC ID Link(s)DYNLL1
KEGG Gene ID(s)hsa:8655
PharmGKB ID(s)PA134972261
General Description of Recombinant Human Dynein light chain 1, cytoplasmic Protein.
Acts as one of several non-catalytic accessory components of the Cytoplasmic domain dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic domain dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from Cytoplasmic domain dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Human Dynein light chain 1, cytoplasmic Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Dynein light chain 1, cytoplasmic based upon sequence from: Human
Host: QP8357 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Dynein light chain 1, cytoplasmic, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8357.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Gly89
Amino Acid Sequence: MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Dynein light chain 1, cytoplasmic Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Dynein light chain 1, cytoplasmic Protein