PDF DatasheetHuman Proteasome subunit alpha type-7 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Proteasome subunit alpha type-7 based upon sequence from: Human
Host: QP8360 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Proteasome subunit alpha type-7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8360.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Arg5 – Ile232
Amino Acid Sequence: RAITVFSPDG HLFQVEYAQE AVKKGSTAVG VRGRDIVVLG VEKKSVAKLQ DERTVRKICA LDDNVCMAFA GLTADARIVI NRARVECQSH RLTVEDPVTV EYITRYIASL KQRYTQSNGR RPFGISALIV GFDFDGTPRL YQTDPSGTYH AWKANAIGRG AKSVREFLEK NYTDEAIETD DLTIKLVIKA LLEVVQSGGK NIELAVMRRD QSLKILNPEE IEKYVAEI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Proteasome subunit alpha type-7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Proteasome subunit alpha type-7 Protein (5-232aa) General Information | |
|---|---|
| Alternate Names | |
| RC6-1; HEL-S-276; HSPC; XAPC7; C6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PSMA7 |
| Entrez Gene ID | 5688 |
| Ensemble Gene ID | ENSG00000101182 |
| RefSeq Protein Accession(s) | NP_002783.1 |
| RefSeq mRNA Accession(s) | NM_002792.3 |
| UniProt ID(s) | O14818 |
| UniGene ID(s) | Hs.233952 |
| HGNC ID(s) | HGNC:9536 |
| COSMIC ID Link(s) | PSMA7 |
| KEGG Gene ID(s) | hsa:5688 |
| PharmGKB ID(s) | PA33881 |
| General Description of Recombinant Human Proteasome subunit alpha type-7 Protein (5-232aa). | |
| The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with AP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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