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Recombinant Human Proteasome subunit alpha type-7 Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8360
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 228

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8360-ec-10ug
Recombinant Human Proteasome subunit alpha type-7 Protein (5-232aa) General Information
Alternate Names
RC6-1; HEL-S-276; HSPC; XAPC7; C6
Curated Database and Bioinformatic Data
Gene SymbolPSMA7
Entrez Gene ID5688
Ensemble Gene IDENSG00000101182
RefSeq Protein Accession(s)NP_002783.1
RefSeq mRNA Accession(s)NM_002792.3
UniProt ID(s)O14818
UniGene ID(s)Hs.233952
HGNC ID(s)HGNC:9536
COSMIC ID Link(s)PSMA7
KEGG Gene ID(s)hsa:5688
PharmGKB ID(s)PA33881
General Description of Recombinant Human Proteasome subunit alpha type-7 Protein (5-232aa).
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with AP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Human Proteasome subunit alpha type-7 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Proteasome subunit alpha type-7 based upon sequence from: Human
Host: QP8360 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Proteasome subunit alpha type-7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8360.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Arg5 - Ile232
Amino Acid Sequence: RAITVFSPDG HLFQVEYAQE AVKKGSTAVG VRGRDIVVLG VEKKSVAKLQ DERTVRKICA LDDNVCMAFA GLTADARIVI NRARVECQSH RLTVEDPVTV EYITRYIASL KQRYTQSNGR RPFGISALIV GFDFDGTPRL YQTDPSGTYH AWKANAIGRG AKSVREFLEK NYTDEAIETD DLTIKLVIKA LLEVVQSGGK NIELAVMRRD QSLKILNPEE IEKYVAEI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Proteasome subunit alpha type-7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Proteasome subunit alpha type-7 Protein