PDF DatasheetHuman Rho guanine nucleotide exchange factor 7 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Rho guanine nucleotide exchange factor 7 based upon sequence from: Human
Host: QP8370 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Rho guanine nucleotide exchange factor 7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8370.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met179 – His428
Amino Acid Sequence: MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG RTGWFPSNYV REVKASEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN ILETENEYSK ELQTVLSTYL RPLQTSEKLS SANISYLMGN LEEICSFQQM LVQSLEECTK LPEAQQRVGG CFLNLMPQMK TLYLTYCANH PSAVNVLTEH SEELGEFMET KGASSPGILV LTTGLSKPFM RLDKYPTLLK ELERHMEDYH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Rho guanine nucleotide exchange factor 7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Rho guanine nucleotide exchange factor 7 Protein (179-428aa) General Information | |
|---|---|
| Alternate Names | |
| COOL1; Nbla10314; BETA-PIX; COOL-1; PAK3; P50BP; PIXB; P85; P85COOL1; P50; P85SPR | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ARHGEF7 |
| Entrez Gene ID | 8874 |
| Ensemble Gene ID | ENSG00000102606 |
| RefSeq Protein Accession(s) | NP_001106983.1 |
| RefSeq mRNA Accession(s) | NM_001113511.2, NM_001113512.2, NM_001113513.1, NM_001320851.1, NM_001320853.1, NM_001320854.1, NM_001330597.1, NM_001330598.1, NM_003899.3, NM_145735.3, XM_017020824.1, XM_017020825.1 |
| UniProt ID(s) | Q14155 |
| UniGene ID(s) | Hs.508738 |
| HGNC ID(s) | HGNC:15607 |
| COSMIC ID Link(s) | ARHGEF7 |
| KEGG Gene ID(s) | hsa:8874 |
| PharmGKB ID(s) | PA24977 |
| General Description of Recombinant Human Rho guanine nucleotide exchange factor 7 Protein (179-428aa). | |
| Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce mbrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions . May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.3 Publications | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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