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Recombinant Human Replication protein A 32 kDa subunit Protein

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SKU: QP8374
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 267

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SKU: QP8374-ec-10ug
Recombinant Human Replication protein A 32 kDa subunit Protein General Information
Alternate Names
RP-A p32; RPA32; RP-A p34; REPA2
Curated Database and Bioinformatic Data
Gene SymbolRPA2
Entrez Gene ID6118
Ensemble Gene IDENSG00000117748
RefSeq Protein Accession(s)NP_001273005.1
RefSeq mRNA Accession(s)NM_001286076.1, NM_001297558.1, NM_002946.4
UniProt ID(s)P15927
UniGene ID(s)Hs.79411
HGNC ID(s)HGNC:10290
COSMIC ID Link(s)RPA2
KEGG Gene ID(s)hsa:6118
PharmGKB ID(s)PA34652
General Description of Recombinant Human Replication protein A 32 kDa subunit Protein.
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance

Human Replication protein A 32 kDa subunit Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Replication protein A 32 kDa subunit based upon sequence from: Human
Host: QP8374 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Replication protein A 32 kDa subunit, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8374.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - Thr267
Amino Acid Sequence: MWNSGFESYG SSSYGGAGGY TQSPGGFGSP APSQAEKKSR ARAQHIVPCT ISQLLSATLV DEVFRIGNVE ISQVTIVGII RHAEKAPTNI VYKIDDMTAA PMDVRQWVDT DDTSSENTVV PPETYVKVAG HLRSFQNKKS LVAFKIMPLE DMNEFTTHIL EVINAHMVLS KANSQPSAGR APISNPGMSE AGNFGGNSFM PANGLTVAQN QVLNLIKACP RPEGLNFQDL KNQLKHMSVS SIKQAVDFLS NEGHIYSTVD DDHFKST
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Replication protein A 32 kDa subunit Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Replication protein A 32 kDa subunit Protein