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Recombinant Human X-ray repair cross-complementing protein 1

$ 148.00$ 1,728.00
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SKU: QP8378
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 217

Size
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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8378-ec-10ug
Recombinant Human X-ray repair cross-complementing protein 6 Protein General Information
Alternate Names
CTC75; ML8; KU70; TLAA; CTCBF; G22P1
Curated Database and Bioinformatic Data
Gene SymbolXRCC6
Entrez Gene ID2547
Ensemble Gene IDENSG00000196419
RefSeq Protein Accession(s)NP_001275905.1
RefSeq mRNA Accession(s)NM_001288976.1, NM_001288977.1, NM_001469.4
UniProt ID(s)P12956
UniGene ID(s)Hs.292493
HGNC ID(s)HGNC:4055
COSMIC ID Link(s)XRCC6
KEGG Gene ID(s)hsa:2547
PharmGKB ID(s)PA28467
General Description of Recombinant Human X-ray repair cross-complementing protein 6 Protein.
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing th together. The assbly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription

Human X-ray repair cross-complementing protein 6 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant X-ray repair cross-complementing protein 6 based upon sequence from: Human
Host: QP8378 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) X-ray repair cross-complementing protein 6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8378.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser6 - Ser222
Amino Acid Sequence: SYYKTEGDEE AEEEQEENLE ASGDYKYSGR DSLIFLVDAS KAMFESQSED ELTPFDMSIQ CIQSVYISKI ISSDRDLLAV VFYGTEKDKN SVNFKNIYVL QELDNPGAKR ILELDQFKGQ QGQKRFQDMM GHGSDYSLSE VLWVCANLFS DVQFKMSHKR IMLFTNEDNP HGNDSAKASR ARTKAGDLRD TGIFLDLMHL KKPGGFDISL FYRDIIS
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human X-ray repair cross-complementing protein 6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human X-ray repair cross-complementing protein 1