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Recombinant Human ENSA / Endosulfine alpha Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8383
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 121

Size
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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8383-ec-10ug
Recombinant Human ENSA / Endosulfine alpha Protein General Information
Alternate Names
ENSA; Endosulfine alpha; ARPP-19e
Curated Database and Bioinformatic Data
Gene SymbolENSA
Entrez Gene ID2029
Ensemble Gene IDENSG00000143420
RefSeq Protein Accession(s)NP_004427.1
RefSeq mRNA Accession(s)NM_004436.2, NM_207042.1, NM_207043.1, NM_207044.1, NM_207045.1, NM_207046.1, NM_207047.1, NM_207168.1
UniProt ID(s)O43768
UniGene ID(s)Hs.632456
HGNC ID(s)HGNC:3360
COSMIC ID Link(s)ENSA
KEGG Gene ID(s)hsa:2029
PharmGKB ID(s)PA27796
General Description of Recombinant Human ENSA / Endosulfine alpha Protein.
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase . Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.1 Publication

Human ENSA / Endosulfine alpha Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant ENSA / Endosulfine alpha based upon sequence from: Human
Host: QP8383 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ENSA / Endosulfine alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8383.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Glu121
Amino Acid Sequence: MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ENSA / Endosulfine alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human ENSA / Endosulfine alpha Protein