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Recombinant Human FKBP12 / FKBP1A Protein

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SKU: QP8403
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 102

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On Demand Protein: 3-5 Week Lead Time. (Why?)
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8403-ec-10ug
Recombinant Human FKBP12 / FKBP1A Protein General Information
Alternate Names
FKBP12; FKBP1A; PPIASE; FKBP12; PKCI2; FKBP1; PKC12; FKBP-12; FKBP-1A
Curated Database and Bioinformatic Data
Gene SymbolFKBP1A
Entrez Gene ID2280
Ensemble Gene IDENSG00000088832
RefSeq Protein Accession(s)NP_000792.1
RefSeq mRNA Accession(s)NM_000801.4, NM_054014.3
UniProt ID(s)P62942
UniGene ID(s)Hs.471933
HGNC ID(s)HGNC:3711
COSMIC ID Link(s)FKBP1A
KEGG Gene ID(s)hsa:2280
PharmGKB ID(s)PA28153
General Description of Recombinant Human FKBP12 / FKBP1A Protein.
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Human FKBP12 / FKBP1A Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant FKBP12 / FKBP1A based upon sequence from: Human
Host: QP8403 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) FKBP12 / FKBP1A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8403.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly2 - Glu103
Amino Acid Sequence: GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKFDSSR DRNKPFKFML GKQEVIRGWE EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human FKBP12 / FKBP1A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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