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Recombinant Human Heterogeneous nuclear ribonucleoprotein 1

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SKU: QP8415
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 457

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On Demand Protein: 3-5 Week Lead Time. (Why?)
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8415-ec-10ug
Recombinant Human Heterogeneous nuclear ribonucleoprotein K Protein General Information
Alternate Names
AUKS; TUNP; CSBP; HNRPK
Curated Database and Bioinformatic Data
Gene SymbolHNRPK
Entrez Gene ID3190
Ensemble Gene IDENSG00000165119
RefSeq Protein Accession(s)NP_001305115.1
RefSeq mRNA Accession(s)NM_001318186.1, NM_001318187.1, NM_001318188.1, NM_002140.4, NM_031262.3, NM_031263.3, XM_005251960.2, XM_005251963.3, XM_005251965.2, XM_017014668.1
UniProt ID(s)P61978
UniGene ID(s)Hs.522257
HGNC ID(s)HGNC:5044
KEGG Gene ID(s)hsa:3190
PharmGKB ID(s)PA162391350
General Description of Recombinant Human Heterogeneous nuclear ribonucleoprotein K Protein.
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction . As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.3 Publications

Human Heterogeneous nuclear ribonucleoprotein K Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Heterogeneous nuclear ribonucleoprotein K based upon sequence from: Human
Host: QP8415 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Heterogeneous nuclear ribonucleoprotein K, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8415.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Thr3 - Ser459
Amino Acid Sequence: TEQPEETFPN TETNGEFGKR PAEDMEEEQA FKRSRNTDEM VELRILLQSK NAGAVIGKGG KNIKALRTDY NASVSVPDSS GPERILSISA DIETIGEILK KIIPTLEEGL QLPSPTATSQ LPLESDAVEC LNYQHYKGSD FDCELRLLIH QSLAGGIIGV KGAKIKELRE NTQTTIKLFQ ECCPHSTDRV VLIGGKPDRV VECIKIILDL ISESPIKGRA QPYDPNFYDE TYDYGGFTMM FDDRRGRPVG FPMRGRGGFD RMPPGRGGRP MPPSRRDYDD MSPRRGPPPP PPGRGGRGGS RARNLPLPPP PPPRGGDLMA YDRRGRPGDR YDGMVGFSAD ETWDSAIDTW SPSEWQMAYE PQGGSGYDYS YAGGRGSYGD LGGPIITTQV TIPKDLAGSI IGKGGQRIKQ IRHESGASIK IDEPLEGSED RIITITGTQD QIQNAQYLLQ NSVKQYS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Heterogeneous nuclear ribonucleoprotein K Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Heterogeneous nuclear ribonucleoprotein 1