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Recombinant Human NME1 / NDKA Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8426
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 151

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8426-ec-10ug
Recombinant Human NME1 / NDKA Protein General Information
Alternate Names
NME1; NDKA; GAAD; NB; AWD; NBS; NDPK-A; NDPKA; NDKA; NM23; NM23-H1
Curated Database and Bioinformatic Data
Gene SymbolNME1
Entrez Gene ID4830
Ensemble Gene IDENSG00000239672
RefSeq Protein Accession(s)NP_000260.1
RefSeq mRNA Accession(s)NM_000269.2, NM_198175.1
UniProt ID(s)P15531
UniGene ID(s)Hs.463456
HGNC ID(s)HGNC:7849
COSMIC ID Link(s)NME1
KEGG Gene ID(s)hsa:4830
PharmGKB ID(s)PA249
General Description of Recombinant Human NME1 / NDKA Protein.
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 roves bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Human NME1 / NDKA Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant NME1 / NDKA based upon sequence from: Human
Host: QP8426 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NME1 / NDKA, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8426.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 - Glu152
Amino Acid Sequence: ANCERTFIAI KPDGVQRGLV GEIIKRFEQK GFRLVGLKFM QASEDLLKEH YVDLKDRPFF AGLVKYMHSG PVVAMVWEGL NVVKTGRVML GETNPADSKP GTIRGDFCIQ VGRNIIHGSD SVESAEKEIG LWFHPEELVD YTSCAQNWIY E
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human NME1 / NDKA Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human NME1 / NDKA Protein