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Recombinant Human Protein arginine N-methyltransferase 1 Protein

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SKU: QP8434
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 248

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Reconsitution Instructions (Leave Blank if Liquid):

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SKU: QP8434-ec-10ug
Recombinant Human Protein arginine N-methyltransferase 1 Protein General Information
Alternate Names
HRMT1L2; ANM1; HCP1; IR1B4
Curated Database and Bioinformatic Data
Gene SymbolPRMT1
Entrez Gene ID3276
Ensemble Gene IDENSG00000126457
RefSeq Protein Accession(s)NP_001527.3
RefSeq mRNA Accession(s)NM_001536.5, NM_198318.4, XM_017026734.1, XM_017026735.1
UniProt ID(s)Q99873
UniGene ID(s)Hs.20521
HGNC ID(s)HGNC:5187
COSMIC ID Link(s)PRMT1
KEGG Gene ID(s)hsa:3276
PharmGKB ID(s)PA29461
General Description of Recombinant Human Protein arginine N-methyltransferase 1 Protein.
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity

Human Protein arginine N-methyltransferase 1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Protein arginine N-methyltransferase 1 based upon sequence from: Human
Host: QP8434 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein arginine N-methyltransferase 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8434.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - Tyr248
Amino Acid Sequence: MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV DPKQLVTNAC LIKEVDIY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein arginine N-methyltransferase 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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    Recombinant Human Protein arginine N-methyltransferase 1 Protein