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Recombinant Human GATE-16 / GABARAPL2 Protein

$ 168.00$ 1,938.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8448
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 117

Size
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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8448-ec-500ug
Recombinant Human GATE-16 / GABARAPL2 Protein General Information
Alternate Names
GATE-16; GABARAPL2; GEF2; GATE-16; GEF-2; ATG8; ATG8C; GATE16
Curated Database and Bioinformatic Data
Gene SymbolGABARAPL2
Entrez Gene ID11345
Ensemble Gene IDENSG00000034713
RefSeq Protein Accession(s)NP_009216.1
RefSeq mRNA Accession(s)NM_007285.6
UniProt ID(s)P60520
UniGene ID(s)Hs.461379
HGNC ID(s)HGNC:13291
COSMIC ID Link(s)GABARAPL2
KEGG Gene ID(s)hsa:11345
PharmGKB ID(s)PA28482
General Description of Recombinant Human GATE-16 / GABARAPL2 Protein.
Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 . Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirents and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore mbrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Human GATE-16 / GABARAPL2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant GATE-16 / GABARAPL2 based upon sequence from: Human
Host: QP8448 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) GATE-16 / GABARAPL2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8448.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Phe117
Amino Acid Sequence: MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GATE-16 / GABARAPL2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human GATE-16 / GABARAPL2 Protein