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Recombinant Human Heat shock protein 75 kDa, mitochondrial Protein

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SKU: QP8452
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 249

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Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8452-ec-10ug
Recombinant Human Heat shock protein 75 kDa, mitochondrial Protein General Information
Alternate Names
TRAP-1; HSP90L; HSP 75; HSP75
Curated Database and Bioinformatic Data
Gene SymbolOTUB1
Entrez Gene ID10131
Ensemble Gene IDENSG00000126602
RefSeq Protein Accession(s)NP_001258978.1
RefSeq mRNA Accession(s)NM_001272049.1, NM_016292.2
UniProt ID(s)Q12931
UniGene ID(s)Hs.30345
HGNC ID(s)HGNC:16264
COSMIC ID Link(s)OTUB1
KEGG Gene ID(s)hsa:10131
PharmGKB ID(s)PA36781
General Description of Recombinant Human Heat shock protein 75 kDa, mitochondrial Protein.
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Human Heat shock protein 75 kDa, mitochondrial Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Heat shock protein 75 kDa, mitochondrial based upon sequence from: Human
Host: QP8452 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Heat shock protein 75 kDa, mitochondrial, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8452.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser60 - Glu308
Amino Acid Sequence: STQTAEDKEE PLHSIISSTE SVQGSTSKHE FQAETKKLLD IVARSLYSEK EVFIRELISN ASDALEKLRH KLVSDGQALP EMEIHLQTNA EKGTITIQDT GIGMTQEELV SNLGTIARSG SKAFLDALQN QAEASSKIIG QFGVGFYSAF MVADRVEVYS RSAAPGSLGY QWLSDGSGVF EIAEASGVRT GTKIIIHLKS DCKEFSSEAR VRDVVTKYSN FVSFPLYLNG RRMNTLQAIW MMDPKDVRE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Heat shock protein 75 kDa, mitochondrial Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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    Recombinant Human Heat shock protein 75 kDa, mitochondrial Protein