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Recombinant Human G-protein coupled receptor 161 Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8467
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 28

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8467-ec-10ug
Recombinant Human G-protein coupled receptor 161 Protein General Information
Alternate Names
RE2
Curated Database and Bioinformatic Data
Gene SymbolGPR161
Entrez Gene ID23432
Ensemble Gene IDENSG00000143147
RefSeq Protein Accession(s)NP_001254538.1
RefSeq mRNA Accession(s)NM_001267609.1, NM_001267610.1, NM_001267612.1, NM_001267613.1, NM_001267614.1, NM_153832.2, XM_005245055.2, XM_005245056.2, XM_005245057.4, XM_011509375.2, XM_011509376.2, XM_011509377.1, XM_011509378.1, XM_017000859.1, XM_017000860.1, XM_017000861.1, XM_017000862.1
UniProt ID(s)Q8N6U8
UniGene ID(s)Hs.271809
HGNC ID(s)HGNC:23694
COSMIC ID Link(s)GPR161
KEGG Gene ID(s)hsa:23432
PharmGKB ID(s)PA134931474
General Description of Recombinant Human G-protein coupled receptor 161 Protein.
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown .

Human G-protein coupled receptor 161 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant G-protein coupled receptor 161 based upon sequence from: Human
Host: QP8467 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) G-protein coupled receptor 161, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8467.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - Ile28
Amino Acid Sequence: MSLNSSLSCR KELSNLTEEE GGEGGVII
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human G-protein coupled receptor 161 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human G-protein coupled receptor 161 Protein