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Recombinant Human Charged multivesicular body protein 2a

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8478
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 222

Size
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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8478-ec-10ug
Recombinant Human Charged multivesicular body protein 2a Protein General Information
Alternate Names
BC2; VPS2; CHMP2; VPS2A; BC-2
Curated Database and Bioinformatic Data
Gene SymbolBC2
Entrez Gene ID27243
Ensemble Gene IDENSG00000130724
RefSeq Protein Accession(s)NP_055268.1
RefSeq mRNA Accession(s)NM_014453.3, NM_198426.2
UniProt ID(s)O43633
UniGene ID(s)Hs.12107
HGNC ID(s)HGNC:30216
KEGG Gene ID(s)hsa:27243
PharmGKB ID(s)PA142672111
General Description of Recombinant Human Charged multivesicular body protein 2a Protein.
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting mbrane of the endosome and mostly are delivered to lysosomes enabling degradation of mbrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating mbrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent mbrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or mbrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Human Charged multivesicular body protein 2a Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Charged multivesicular body protein 2a based upon sequence from: Human
Host: QP8478 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Charged multivesicular body protein 2a, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8478.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Asp222
Amino Acid Sequence: MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Charged multivesicular body protein 2a Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Charged multivesicular body protein 2a