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Recombinant Human Breast cancer metastasis-suppressor 1 Protein

$ 148.00$ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8482
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 235

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8482-ec-10ug
Recombinant Human Breast cancer metastasis-suppressor 1 Protein General Information
Curated Database and Bioinformatic Data
Gene SymbolBRMS1
Entrez Gene ID25855
Ensemble Gene IDENSG00000174744
RefSeq Protein Accession(s)NP_056214.1
RefSeq mRNA Accession(s)NM_015399.3
UniProt ID(s)Q9HCU9
UniGene ID(s)Hs.100426
HGNC ID(s)HGNC:17262
COSMIC ID Link(s)BRMS1
KEGG Gene ID(s)hsa:25855
PharmGKB ID(s)PA164741342
General Description of Recombinant Human Breast cancer metastasis-suppressor 1 Protein.
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Human Breast cancer metastasis-suppressor 1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Breast cancer metastasis-suppressor 1 based upon sequence from: Human
Host: QP8482 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Breast cancer metastasis-suppressor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8482.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - Ala235
Amino Acid Sequence: MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE YTEPLGGLQR SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL LLYDTLQGEL QERIQRLEED RQSLDLSSEW WDDKLHARGS SRSWDSLPPS KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Breast cancer metastasis-suppressor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Breast cancer metastasis-suppressor 1 Protein