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Recombinant Human Programmed cell death protein 1

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8484
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 191

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8484-ec-10ug
Recombinant Human Programmed cell death protein 6 Protein General Information
Alternate Names
ALG2; PEF1B; ALG-2
Curated Database and Bioinformatic Data
Gene SymbolALG2
Entrez Gene ID10016
Ensemble Gene IDENSG00000249915
RefSeq Protein Accession(s)NP_001254485.1
RefSeq mRNA Accession(s)NM_001267556.1, NM_001267557.1, NM_001267558.1, NM_001267559.1, NM_013232.3
UniProt ID(s)O75340
UniGene ID(s)Hs.50823
HGNC ID(s)HGNC:8765
COSMIC ID Link(s)ALG2
KEGG Gene ID(s)hsa:10016
PharmGKB ID(s)PA33115
General Description of Recombinant Human Programmed cell death protein 6 Protein.
Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca2+-regulated signals along the death pathway . Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Ses to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca2+ affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.5 Publications

Human Programmed cell death protein 6 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Programmed cell death protein 6 based upon sequence from: Human
Host: QP8484 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Programmed cell death protein 6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8484.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Val191
Amino Acid Sequence: MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Programmed cell death protein 6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Programmed cell death protein 1