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Recombinant Human PRKCA-binding Protein

$ 168.00$ 1,938.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8506
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 200

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8506-ec-10ug
Recombinant Human PRKCA-binding protein Protein General Information
Alternate Names
PICK; PRKCABP
Curated Database and Bioinformatic Data
Gene SymbolPICK1
Entrez Gene ID9463
Ensemble Gene IDENSG00000100151
RefSeq Protein Accession(s)NP_001034672.1
RefSeq mRNA Accession(s)NM_001039583.1, NM_001039584.1, NM_012407.3
UniProt ID(s)Q9NRD5
UniGene ID(s)Hs.180871
HGNC ID(s)HGNC:9394
COSMIC ID Link(s)PICK1
KEGG Gene ID(s)hsa:9463
PharmGKB ID(s)PA33760
General Description of Recombinant Human PRKCA-binding protein Protein.
Probable adapter protein that bind to and organize the subcellular localization of a variety of mbrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Human PRKCA-binding protein Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant PRKCA-binding protein based upon sequence from: Human
Host: QP8506 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PRKCA-binding protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8506.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - Gln200
Amino Acid Sequence: MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV QVFDNTPAAL DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH YNKLQADPKQ GMSLDIVLKK VKHRLVENMS SGTADALGLS RAILCNDGLV KRLEELERTA ELYKGMTEHT KNLLRAFYEL SQTHRAFGDV FSVIGVREPQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PRKCA-binding protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human PRKCA-binding Protein