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Recombinant Human CCL5 / RANTES Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8524
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 68

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8524-ec-10ug
Recombinant Human CCL5 / RANTES Protein General Information
Alternate Names
CCL5; RANTES; SISd; TCP228; D17S136E; RANTES; SCYA5; SIS-delta; eoCP
Curated Database and Bioinformatic Data
Gene SymbolCCL5
Entrez Gene ID6352
Ensemble Gene IDENSG00000271503
RefSeq Protein Accession(s)NP_002976.2
RefSeq mRNA Accession(s)NM_002985.2
UniProt ID(s)P13501
UniGene ID(s)Hs.514821
HGNC ID(s)HGNC:10632
KEGG Gene ID(s)hsa:6352
PharmGKB ID(s)PA35564
General Description of Recombinant Human CCL5 / RANTES Protein.
Choattractant for blood monocytes, mory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils . May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells

Human CCL5 / RANTES Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant CCL5 / RANTES based upon sequence from: Human
Host: QP8524 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CCL5 / RANTES, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8524.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser24 - Ser91
Amino Acid Sequence: SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CCL5 / RANTES Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human CCL5 / RANTES Protein