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SDS-PAGE separation of QP8529 followed by commassie total protein stain results in a primary band consistent with reported data for Clusterin. These data demonstrate Greater than 90% as determined by SDS-PAGE.
SDS-PAGE separation of QP8529 followed by commassie total protein stain results in a primary band consistent with reported data for Clusterin. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Clusterin Protein

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SKU: QP8529
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 202

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Product Datasheet
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Reconsitution Instructions (Leave Blank if Liquid):

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Bioactivity (test results eg. IU/ml):


SKU: QP8529-ec-10ug
Recombinant Human Clusterin Protein General Information
Alternate Names
AAG4; NA1/NA2; APO-J; SP-40; CLU1; KUB1; TRPM-2; TRPM2; APOJ; CLU2; SGP-2; CLI; SGP2
Curated Database and Bioinformatic Data
Gene SymbolAPOJ
Entrez Gene ID1191
Ensemble Gene IDENSG00000120885
RefSeq Protein Accession(s)NP_001822.3
RefSeq mRNA Accession(s)NM_001831.3, XM_006716284.2
UniProt ID(s)P10909
UniGene ID(s)Hs.436657
HGNC ID(s)HGNC:2095
KEGG Gene ID(s)hsa:1191
PharmGKB ID(s)PA26620
General Description of Recombinant Human Clusterin Protein.
Isoform 1 functions as Extracellular domain chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complent. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation

Human Clusterin Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Clusterin based upon sequence from: Human
Host: QP8529 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Clusterin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8529.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Asp23 - Arg224
Amino Acid Sequence: DQTVSDNELQ EMSNQGSKYV NKEIQNAVNG VKQIKTLIEK TNEERKTLLS NLEEAKKKKE DALNETRESE TKLKELPGVC NETMMALWEE CKPCLKQTCM KFYARVCRSG SGLVGRQLEE FLNQSSPFYF WMNGDRIDSL LENDRQQTHM LDVMQDHFSR ASSIIDELFQ DRFFTREPQD TYHYLPFSLP HRRPHFFFPK SR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Clusterin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Clusterin Protein

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