SDS-PAGE separation of QP8536 followed by commassie total protein stain results in a primary band consistent with reported data for DKK-1 / Dkk1. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human DKK-1 / Dkk1 Protein

$ 88.00$ 1,618.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8536
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 234

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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8536-ec-10ug
Recombinant Human DKK-1 / Dkk1 Protein General Information
Alternate Names
DKK-1; Dkk1; DKK-1; SK
Curated Database and Bioinformatic Data
Gene SymbolDKK1
Entrez Gene ID22943
Ensemble Gene IDENSG00000107984
RefSeq Protein Accession(s)NP_036374.1
RefSeq mRNA Accession(s)NM_012242.2
UniProt ID(s)O94907
UniGene ID(s)Hs.40499
HGNC ID(s)HGNC:2891
COSMIC ID Link(s)DKK1
KEGG Gene ID(s)hsa:22943
PharmGKB ID(s)PA27345
General Description of Recombinant Human DKK-1 / Dkk1 Protein.
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmbrane protein KREN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Human DKK-1 / Dkk1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant DKK-1 / Dkk1 based upon sequence from: Human
Host: QP8536 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DKK-1 / Dkk1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8536.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu33 - His2
Amino Acid Sequence: LNSVLNSNAI KNLPPPLGGA AGHPGSAVSA APGILYPGGN KYQTIDNYQP YPCAEDEECG TDEYCASPTR GGDAGVQICL ACRKRRKRCM RHAMCCPGNY CKNGICVSSD QNHFRGEIEE TITESFGNDH STLDGYSRRT TLSSKMYHTK GQEGSVCLRS SDCASGLCCA RHFWSKICKP VLKEGQVCTK HRRKGSHGLE IFQRCYCGEG LSCRIQKDHH QASNSSRLHT CQRH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human DKK-1 / Dkk1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human DKK-1 / Dkk1 Protein