SDS-PAGE separation of QP8639 followed by commassie total protein stain results in a primary band consistent with reported data for Glucagon. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Glucagon Protein

$ 148.00$ 2,008.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8639
Species: Human
Available Tags: GST, His
Host: E.coli, Yeast.
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 37

Size
Tag Clear selection
Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8639-ec-10ug
Recombinant Human Glucagon Protein General Information
Alternate Names
GLP1; GRPP; GLP2
Curated Database and Bioinformatic Data
Gene SymbolGCG
Entrez Gene ID2641
Ensemble Gene IDENSG00000115263
RefSeq Protein Accession(s)NP_002045.1
RefSeq mRNA Accession(s)NM_002054.4
UniProt ID(s)P01275
UniGene ID(s)Hs.516494
HGNC ID(s)HGNC:4191
COSMIC ID Link(s)GCG
KEGG Gene ID(s)hsa:2641
PharmGKB ID(s)PA28606
General Description of Recombinant Human Glucagon Protein.
Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycia. Plays an important role in initiating and maintaining hyperglycic conditions in diabetes.GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.Oxyntomodulin significantly reduces food intake. Inhibits gastric ptying in humans. Suppression of gastric ptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.

Human Glucagon Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Glucagon based upon sequence from: Human
Host: QP8639 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Glucagon, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8639.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: His53 - Ala89
Amino Acid Sequence: HSQGTFTSDY SKYLDSRRAQ DFVQWLMNTK RNRNNIA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Glucagon Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Glucagon Protein