SDS-PAGE separation of QP8657 followed by commassie total protein stain results in a primary band consistent with reported data for CXCL12 / SDF-1. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Mouse CXCL12 / SDF-1 Protein

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SKU: QP8657
Species: Mouse
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 68

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Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP8657-ec-10ug

Recombinant Mouse CXCL12 / SDF-1 Protein General Information
Alternate Names
CXCL12; SDF-1; SCYB12; IRH; PBSF; SDF1; TPAR1; TLSF
Curated Database and Bioinformatic Data
Gene Symbol	CXCL12
Entrez Gene ID	20315
Ensemble Gene ID	ENSMUSG00000061353
RefSeq Protein Accession(s)	NP_038683.1
RefSeq mRNA Accession(s)	NM_013655.4, NM_021704.3
UniProt ID(s)	P40224
UniGene ID(s)	Mm.303231
COSMIC ID Link(s)	CXCL12
KEGG Gene ID(s)	mmu:20315
General Description of Recombinant Mouse CXCL12 / SDF-1 Protein.
Choattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chotaxis. Also binds to atypical chokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells . Has several critical functions during bryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.Stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.

Mouse CXCL12 / SDF-1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant CXCL12 / SDF-1 based upon sequence from: Mouse

Host: QP8657 protein expressed in E. coli.

Tag: His

Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) CXCL12 / SDF-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP8657.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Lys22 - Lys89

Amino Acid Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Mouse CXCL12 / SDF-1 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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