SDS-PAGE separation of QP8668 followed by commassie total protein stain results in a primary band consistent with reported data for Ubiquitin-conjugating enzyme E2 K. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Ubiquitin-conjugating enzyme E2 K Protein

$ 148.00$ 1,678.00
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SKU: QP8668
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 199

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Shipping Information
4-6 weeks
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Datasheets and Documentation
Product Datasheet
SKU: QP8668-ec-10ug
Recombinant Human Ubiquitin-conjugating enzyme E2 K Protein General Information
Alternate Names
LIG; E2-25K; HIP2; HYPG; UBC1
Curated Database and Bioinformatic Data
Gene SymbolUBE2K
Entrez Gene ID3093
Ensemble Gene IDENSG00000078140
RefSeq Protein Accession(s)NP_001104582.1
RefSeq mRNA Accession(s)NM_001111112.1, NM_001111113.1, NM_005339.4
UniProt ID(s)P61086
UniGene ID(s)Hs.50308
HGNC ID(s)HGNC:4914
COSMIC ID Link(s)UBE2K
KEGG Gene ID(s)hsa:3093
PharmGKB ID(s)PA162407874
General Description of Recombinant Human Ubiquitin-conjugating enzyme E2 K Protein.
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1

Human Ubiquitin-conjugating enzyme E2 K Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Ubiquitin-conjugating enzyme E2 K based upon sequence from: Human
Host: QP8668 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ubiquitin-conjugating enzyme E2 K, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8668.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 - Asn200
Amino Acid Sequence: ANIAVQRIKR EFKEVLKSEE TSKNQIKVDL VDENFTELRG EIAGPPDTPY EGGRYQLEIK IPETYPFNPP KVRFITKIWH PNISSVTGAI CLDILKDQWA AAMTLRTVLL SLQALLAAAE PDDPQDAVVA NQYKQNPEMF KQTARLWAHV YAGAPVSSPE YTKKIENLCA MGFDRNAVIV ALSSKSWDVE TATELLLSN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Ubiquitin-conjugating enzyme E2 K Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Ubiquitin-conjugating enzyme E2 K Protein