SDS-PAGE separation of QP8673 followed by commassie total protein stain results in a primary band consistent with reported data for Ubiquitin-like protein ISG15. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Ubiquitin-like protein ISG15 Protein

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SKU: QP8673
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 156

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SKU: QP8673-ec-10ug
Recombinant Human Ubiquitin-like protein ISG15 Protein General Information
Alternate Names
UCRP; G1p2; IGI15; Irfp; IP17
Curated Database and Bioinformatic Data
Gene SymbolG1P2
Entrez Gene ID100038882
Ensemble Gene IDENSMUSG00000035692
RefSeq Protein Accession(s)NP_056598.2
RefSeq mRNA Accession(s)NM_015783.3
UniProt ID(s)Q64339
UniGene ID(s)Mm.451527
KEGG Gene ID(s)mmu:100038882
General Description of Recombinant Human Ubiquitin-like protein ISG15 Protein.
Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, TRIM25, STAT5A, MAPK1/ERK2 and globin. Can also isgylate: DDX58/RIG-I which inhibits its function in antiviral signaling response and EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A and B virus, sindbis virus (SV) and herpes simplex type-1 (HHV-1). Plays a significant role in the control of neonatal Chikungunya virus (CHIKV) infection by acting as a putative immunomodulator of proinflammatory cytokines. Protects mice against the consequences of Chikungunya virus infection by downregulating the pathogenic cytokine response, often denoted as the cytokine storm. Plays a role in erythroid differentiation. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity

Human Ubiquitin-like protein ISG15 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Ubiquitin-like protein ISG15 based upon sequence from: Human
Host: QP8673 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ubiquitin-like protein ISG15, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8673.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 - Gly157
Amino Acid Sequence: AWDLKVKMLG GNDFLVSVTN SMTVSELKKQ IAQKIGVPAF QQRLAHQTAV LQDGLTLSSL GLGPSSTVML VVQNCSEPLS ILVRNERGHS NIYEVFLTQT VDTLKKKVSQ REQVHEDQFW LSFEGRPMED KELLGEYGLK PQCTVIKHLR LRGGGG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Ubiquitin-like protein ISG15 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Ubiquitin-like protein ISG15 Protein